All of our DNA template controls are adjusted to a final concentration of 200 ug/ml in 1/10 TE (1mM Tris-HCl (pH8.0), 0.1mM EDTA). This diluent provides sufficient buffering capacity and EDTA to protect the DNA controls without interfering with the Mg+2 concentrations required for robust PCR amplification.

Locus/Target
These DNA template controls yield positive results when used in the appropriate RUO Gene Rearrangement, Gene Translocation, or Gene Mutation Assays.
IGH Gene Rearrangement Controls
IGK Gene Rearrangement Controls
IGL Gene Rearrangement Controls
TCRB Gene Rearrangement Controls
TCRD Gene Rearrangement Controls
TCRG Gene Rearrangement Controls
BCL1/JH t(11;14) Translocation Controls
BCL2/JH t(14;18) Translocation Controls
MLL/AF4 t(4;11) Translocation Controls
FLT3 Gene Mutation Controls

Polyclonal DNA
Human Polyclonal Genomic DNA from Tonsil

All DNA Controls
IVS-0000 - From Human Tissue
IVS-0001 to IVS-0009 - From Cell Lines
IVS-0010 to IVS-0019 - From Cell Lines
IVS-0020 to IVS-0029 - From Cell Lines
IVS-0030 to IVS-0039 - From Cell Lines
IVS-0040 and Higher - From Cell Lines
IVS-P001 to IVS-P003 - From Plasmids

Plasmid DNA controls & calibrators
IVS-P001 Clonal Control DNA
IVS-P002 Clonal Control DNA

All of our RNA template controls are adjusted to a final concentration of 400 ug/ml in RNase-free, glass-distilled water. The pH of distilled water is slightly acidic; this protects the RNA from hydrolysis.

Locus/Target
These RNA template controls yield positive results when used in the appropriate RUO Gene Rearrangement, Gene Translocation, or Gene Mutation Assays.

BCR/ABL t(9;22) Translocation Controls
PML/RARa t(15;17) Translocation Controls
CBFB/MYH11 inv(16) Control
E2A/PBX1 t(1;19) Translocation Controls
AML1/ETO t(8;21) Translocation Control

All RNA Controls
IVS-0001 to IVS-0009 - From Cell Lines      
IVS-0010 to IVS-0019 - From Cell Lines      
IVS-0020 to IVS-0029 - From Cell Lines      
IVS-0030 to IVS-0039 - From Cell Lines      
IVS-0040 to IVS-0044 - From Cell Lines          

We are currently developing and validating a comprehensive selection of non-viable lyophilized cell controls. These controls are produced from control cell lines licensed from the American Type Culture Collection (ATCC) and will be available in a series of serial dilutions of positive cells diluted into negative control cells. Currently we anticipate providing a total of 3x10(6) cells per vial, lyophilized and capped in a dessicated N2 atmosphere, shipped and stored at ambient temperature.

Locus/Target
We anticipate that these RUO controls will be extracted and tested in parallel with specimens when using Gene Rearrangement, Gene Translocation, or Gene Mutation Assays.

BCR/ABL p210 b3a2 cells
BCR/ABL p210 b2a2 cells
BCR/ABL p190 e1a2 cells
BCR/ABL negative cells 

DNA sensitivity panels are 6 member panels that consist of 100% clonal DNA extracted from a clonal cell line and 30%, 20%, 10%, 5% and 1% dilutions of the clonal DNA diluted (v/v) into our standard negative template control DNA, IVS-0000 Polyclonal Control DNA, cat# 4-092-0010.

View all DNA Sensitivity Panels

RNA sensitivity panels are 7 member panels that consist of 100% clonal RNA extracted from a clonal cell line and 10-1, 10-2, 10-3, 10-4, 10-5, and 10-6 dilutions of the clonal RNA diluted (v/v) into our standard negative template control RNA, IVS-0035 Clonal Control RNA.

View All RNA Sensitivity Panels

Our proficiency panels consist of dilutions of positive and negative DNA or RNA template controls. Each proficiency panel is designed to work with a specific assay.

Proficiency Panel for the BCR/ABL t(9;22) Translocations

Proficiency Panel for the PML/RARa t(15;17) Translocations