Medical Conditions

With multiple types and subtypes, NHL can be difficult to classify, diagnose and treat. However, with molecular testing, microscopic examinations of cells and improved genetic testing, NHL can be effectively treated in most patients.

Non-Hodgkin Lymphoma (NHL) Facts

• There are roughly 65,500 cases diagnosed each year in the U.S.
• Non-Hodgkin lymphoma is much more prevalent than Hodgkin lymphoma.
• Non-Hodgkin lymphoma develops, spreads and is treated differently than Hodgkin-lymphoma.
• There is a higher incidence of the most common types of NHL in people in their 60’s and 70’s.
• NHL can occur in people of all ages including children.
• NHL is more common in men than in women.
• In adults, indolent (slow progressing) and aggressive (fast growing) NHL are equally common.
• In children, aggressive NHL is more common than indolent.

 

Risk Factors for Non-Hodgkin Lymphoma

• Exposure to chemicals, such as insect and weed killers, may increase the risk of developing NHL.

• An increased risk for developing NHL is associated with viruses such as HIV, Hepatitis C, Epstein-Barr and the bacteria H-Pylori.

• Immunosuppressive therapy for organ transplant patients reduces the bodies ability to fight off new illnesses thus making one more susceptible to developing NHL.

Symptoms of Non-Hodgkin Lymphoma

Many common illnesses can cause symptoms similar to NHL so it is best to alert your doctor if they are persistent or recurring. Symptoms of NHL include swollen lymph nodes, pain and swelling of the abdomen, coughing, chest pain, fatigue, weight loss and night sweats.

 

Diagnosing Non-Hodgkin Lymphoma

A physical exam will be performed focusing on the size and condition of lymph nodes and checking for enlarged spleen and liver. Blood and urine tests will help identify infections and other diseases. X-rays, CT scans, MRI scans and PET scans can reveal tumors, examine the brain and spinal cord, and help determine the stage of NHL if it is detected. A biopsy of lymph node tissue can help identify the type of NHL present. A biopsy of bone marrow can tell whether the disease has spread.

Treatment of Non-Hodgkin Lymphoma

If indolent lymphoma is present and a patient is otherwise healthy and symptom free, treatment can be postponed. During this time, which is referred to as “watchful waiting,” a patient will be monitored and tested regularly. If symptoms occur or the cancer appears to be progressing, treatment will commence.

Treatment for NHL most often includes chemotherapy. Depending on the stage and type of NHL, radiation, immunotherapy, stem cell and bone marrow transplantations may be employed. It is always advisable to inquire regarding participation in ongoing clinical trials and ask your doctor about emerging therapies.

Alternate Names for Non-Hodgkin lymphoma
Non-Hodgkin lymphoma is also known as non-Hodgkin’s lymphoma.